Optimization of an accelerator-based epithermal neutron source for neutron capture therapy.
نویسندگان
چکیده
A modeling investigation was performed to choose moderator material and size for creating optimal epithermal neutron beams for BNCT based on a proton accelerator and the (7)Li(p,n)(7)Be reaction as a neutrons source. An optimal configuration is suggested for the beam shaping assembly made from polytetrafluoroethylene and magnesium fluorine to be placed on high current IPPE proton accelerator KG-2.5. Results of calculation were experimentally tested and are in good agreement with measurements.
منابع مشابه
Design and Simulation of Photoneutron Source by MCNPX Monte Carlo Code for Boron Neutron Capture Therapy
Introduction Electron linear accelerator (LINAC) can be used for neutron production in Boron Neutron Capture Therapy (BNCT). BNCT is an external radiotherapeutic method for the treatment of some cancers. In this study, Varian 2300 C/D LINAC was simulated as an electron accelerator-based photoneutron source to provide a suitable neutron flux for BNCT. Materials and Methods Photoneutron sources w...
متن کاملAn investigation into the potential applicability of gel dosimeters for dosimetry in boron neutron capture therapy
Background: The aim of this work was to establish how well gel dosimeters performed, as substitutes for brain tissue compared with standard phantom materials such as water, polymethyl-methacrylate (or PMMA), A150 plastic and TE- liquid phantom material for dosimetry of neutron beams in boron neutron capture therapy. Materials and Methods: Thermal neutron fluence, photon dose and epithermal neu...
متن کاملطراحی و بهینه‌سازی طیف نوترونی برای درمان تومورهای عمیق مغزی به روش BNCT با کاهش آسیب رسیده به پوست
Boron neutron capture therapy (BNCT) is an effective method for treatment of deep seated brain tumors. This method consists of two stages: injection of boron compound in the patient body, and then irradiation of the region tumors with the neutron beam. It allows for delivery of high linear energy transfer (LET) radiation (particles 4He and 7Li nuclei) to tumors at the cellular level whilst avoi...
متن کاملOptimum neutron energy simulation in treatment of head and neck cancer at different depths in the BNCT method
Introduction: Recently head and neck cancer has pay attention to many researchers. Its therapeutic methods include surgery, chemotherapy, radiotherapy and Boron neutron capture therapy (BNCT). BNCT is better than conventional radiotherapy because it targets the tumor cell. This method involves two steps of infusion of stable 10B and then neutron radiation with a suitable intens...
متن کاملClinical Requirements and Accelerator Concepts for Bnct
Accelerator-based neutron sources are an attractive alternative to nuclear reactors for providing epithermal neutron beams for Boron Neutron Capture Therapy. Based on clinical requirements and neutronics modeling the use of proton and deuteron induced reactions in 7Li and 9Be targets has been compared. Excellent epithermal neutron beams can be produced via the 7Li(p,n)7Be reaction at proton ene...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
دوره 61 5 شماره
صفحات -
تاریخ انتشار 2004